Ontology highlight
ABSTRACT:
SUBMITTER: Iuchi S
PROVIDER: S-EPMC151354 | biostudies-literature | 2003 Mar
REPOSITORIES: biostudies-literature
Iuchi S S Hoffner G G Verbeke P P Djian P P Green H H
Proceedings of the National Academy of Sciences of the United States of America 20030218 5
Neurological diseases resulting from proteins containing expanded polyglutamine (polyQ) are characteristically associated with insoluble neuronal inclusions, usually intranuclear, and neuronal death. We describe here oligomeric and polymeric aggregates formed in cells by expanded polyQ. These aggregates are not dissociated by concentrated formic acid, an extremely effective solvent for otherwise insoluble proteins. Perinuclear inclusions formed in cultured cells by expanded polyQ can be complete ...[more]