Systematic review of genetic association studies involving histologically confirmed non-alcoholic fatty liver disease.

ABSTRACT:

Unlabelled

Non-alcoholic fatty liver disease has an increasing prevalence in Western countries, affecting up to 20% of the population.

Objective

The aim of this project was to systematically review and summarise the genetic association studies that investigate possible genetic influences that confer susceptibility to non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.

Design

The MEDLINE and SCOPUS databases were searched to identify candidate gene studies on histologically diagnosed non-alcoholic fatty liver disease.

Results

A total of 85 articles have been summarised and categorised on the basis of the general pathway each candidate gene is involved in, including lipid metabolism, lipoprotein processing, cholesterol synthesis, glucose homoeost

SUBMITTER: Wood KL 

PROVIDER: S-EPMC4599155 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature