Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies.
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ABSTRACT:
SUBMITTER: Lee YH
PROVIDER: S-EPMC4820743 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
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Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies.
Lee Yong-Ho YH Lee Sang-Guk SG Lee Chan Joo CJ Kim Soo Hyun SH Song Young-Mi YM Yoon Mi Ra MR Jeon Byung Hun BH Lee Jae Hyuk JH Lee Byung-Wan BW Kang Eun Seok ES Lee Hyun Chul HC Cha Bong-Soo BS
Scientific reports 20160405
Betatrophin/angiopoietin-like protein 8 (ANGPTL8) is a liver-secreted protein recently identified as a potent stimulator of beta cell proliferation in mice. However, it is unclear how betatrophin is regulated in humans with non-alcoholic fatty liver disease (NAFLD). We investigated the role of betatrophin in mice and in humans with and without NAFLD. Serum betatrophin levels were examined by ELISA in 164 subjects, including 96 patients with NAFLD. Levels were significantly elevated in subjects w ...[more]
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