Ontology highlight
ABSTRACT:
SUBMITTER: Muller J
PROVIDER: S-EPMC4599183 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Müller Judith J Maurer Viktor V Reimers Kerstin K Vogt Peter M PM Bucan Vesna V
International journal of oncology 20150916 5
Lifeguard (LFG) is a transmembrane protein which is highly expressed in tissues of the hippocampus and the cerebellum, especially during postnatal development. This protein is responsible for the protection of neurons against Fas-induced apoptosis, and the same effect can be seen in tumor cells derived from mastocarcinoma. However, the molecular function of LFG and its regulation in the carcinogenesis of human breast cells remains to be elucidated. In the present study, we investigated the conne ...[more]