Ontology highlight
ABSTRACT:
SUBMITTER: Jia M
PROVIDER: S-EPMC4600727 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Jia Min M Shan Zelin Z Yang Ying Y Liu Chunhua C Li Jianchao J Li Jianchao J Luo Zhen-Ge ZG Zhang Mingjie M Cai Yu Y Wen Wenyu W Wang Wenning W
Nature communications 20151001
During the asymmetric division of Drosophila neuroblasts (NBs), the scaffold Miranda (Mira) coordinates the subcellular distribution of cell-fate determinants including Staufen (Stau) and segregates them into the ganglion mother cells (GMCs). Here we show the fifth double-stranded RNA (dsRNA)-binding domain (dsRBD5) of Stau is necessary and sufficient for binding to a coiled-coil region of Mira cargo-binding domain (CBD). The crystal structure of Mira514-595/Stau dsRBD5 complex illustrates that ...[more]