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Enhancement of Selectivity of an Organometallic Anticancer Agent by Redox Modulation.

ABSTRACT: Combination with redox modulators can potentiate the anticancer activity and maximize the selectivity of organometallic complexes with redox-based mechanisms of action. We show that nontoxic doses of l-buthionine sulfoximine increase the selectivity of organo-Os complex FY26 for human ovarian cancer cells versus normal lung fibroblasts to 63-fold. This increase is not due to changes in the mechanism of action of FY26 but to the decreased response of cancer cells to oxidative stress.

SUBMITTER: Romero-Canelon I

PROVIDER: S-EPMC4601049 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Enhancement of Selectivity of an Organometallic Anticancer Agent by Redox Modulation.

Romero-Canelón Isolda I Mos Magdalena M Sadler Peter J PJ

Journal of medicinal chemistry 20150923 19

Combination with redox modulators can potentiate the anticancer activity and maximize the selectivity of organometallic complexes with redox-based mechanisms of action. We show that nontoxic doses of l-buthionine sulfoximine increase the selectivity of organo-Os complex FY26 for human ovarian cancer cells versus normal lung fibroblasts to 63-fold. This increase is not due to changes in the mechanism of action of FY26 but to the decreased response of cancer cells to oxidative stress. ...[more]

PMID: 26397305

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