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A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells.


ABSTRACT: Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow for simultaneous treatment and visualization of cancer is urgent. Herein, we demonstrate a novel bifunctional mitochondria-targeted anticancer agent (FPB), exhibiting both imaging capability and anticancer activity. It can selectively accumulate in mitochondria and induce cell apoptosis. Notably, it results in much higher toxicity toward cancer cells owing to much higher uptake by cancer cells. These features make it highly attractive in cancer imaging and treatment.

SUBMITTER: He H 

PROVIDER: S-EPMC4559806 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells.

He Huan H   Li Dong-Wei DW   Yang Li-Yun LY   Fu Li L   Zhu Xun-Jin XJ   Wong Wai-Kwok WK   Jiang Feng-Lei FL   Liu Yi Y  

Scientific reports 20150904


Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow for simultaneous treatment and visualization of cancer is urgent. Herein, we demonstrate a novel bifunctional mitochondria-targeted anticancer agent (FPB), exhibiting both imaging capability and anticancer activity. It can selectively accumulate in mitochondria and induce cell apoptosis. Notably, it results in much  ...[more]

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