Ontology highlight
ABSTRACT:
SUBMITTER: He H
PROVIDER: S-EPMC4559806 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
He Huan H Li Dong-Wei DW Yang Li-Yun LY Fu Li L Zhu Xun-Jin XJ Wong Wai-Kwok WK Jiang Feng-Lei FL Liu Yi Y
Scientific reports 20150904
Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow for simultaneous treatment and visualization of cancer is urgent. Herein, we demonstrate a novel bifunctional mitochondria-targeted anticancer agent (FPB), exhibiting both imaging capability and anticancer activity. It can selectively accumulate in mitochondria and induce cell apoptosis. Notably, it results in much ...[more]