A novel form of ciliopathy underlies hyperphagia and obesity in Ankrd26 knockout mice.
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ABSTRACT:
SUBMITTER: Acs P
PROVIDER: S-EPMC4601608 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
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A novel form of ciliopathy underlies hyperphagia and obesity in Ankrd26 knockout mice.
Acs Peter P Bauer Peter O PO Mayer Balazs B Bera Tapan T Macallister Rhonda R Mezey Eva E Pastan Ira I
Brain structure & function 20140316 3
Human ciliopathies are genetic disorders caused by mutations in genes responsible for the formation and function of primary cilia. Some are associated with hyperphagia and obesity (e.g., Bardet-Biedl Syndrome, Alström Syndrome), but the mechanisms underlying these problems are not fully understood. The human gene ANKRD26 is located on 10p12, a locus that is associated with some forms of hereditary obesity. Previously, we reported that disruption of this gene causes hyperphagia, obesity and gigan ...[more]
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