Fine mapping of chromosome 15q25 implicates ZNF592 in neurosarcoidosis patients.
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ABSTRACT:
SUBMITTER: Lareau CA
PROVIDER: S-EPMC4603380 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Fine mapping of chromosome 15q25 implicates ZNF592 in neurosarcoidosis patients.
Lareau Caleb A CA Adrianto Indra I Levin Albert M AM Iannuzzi Michael C MC Rybicki Benjamin A BA Montgomery Courtney G CG
Annals of clinical and translational neurology 20150731 10
Neurosarcoidosis is a clinical subtype of sarcoidosis characterized by the presence of granulomas in the nervous system. Here, we report a highly significant association with a variant (rs75652600, P = 3.12 × 10(-8), odds ratios = 4.34) within a zinc finger gene, ZNF592, from an imputation-based fine-mapping study of the chromosomal region 15q25 in African-Americans with neurosarcoidosis. We validate the association with ZNF592, a gene previously shown to cause cerebellar ataxia, in a cohort of ...[more]
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