Ontology highlight
ABSTRACT:
SUBMITTER: Sandiego CM
PROVIDER: S-EPMC4603509 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Sandiego Christine M CM Gallezot Jean-Dominique JD Pittman Brian B Nabulsi Nabeel N Lim Keunpoong K Lin Shu-Fei SF Matuskey David D Lee Jae-Yun JY O'Connor Kevin C KC Huang Yiyun Y Carson Richard E RE Hannestad Jonas J Cosgrove Kelly P KP
Proceedings of the National Academy of Sciences of the United States of America 20150918 40
Neuroinflammation is associated with a broad spectrum of neurodegenerative and psychiatric diseases. The core process in neuroinflammation is activation of microglia, the innate immune cells of the brain. We measured the neuroinflammatory response produced by a systemic administration of the Escherichia coli lipopolysaccharide (LPS; also called endotoxin) in humans with the positron emission tomography (PET) radiotracer [11C]PBR28, which binds to translocator protein, a molecular marker that is ...[more]