Ontology highlight
ABSTRACT:
SUBMITTER: Xu TY
PROVIDER: S-EPMC4603696 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Xu Tian-Ying TY Zhang Sai-Long SL Dong Guo-Qiang GQ Liu Xin-Zhu XZ Wang Xia X Lv Xiao-Qun XQ Qian Qi-Jun QJ Zhang Ruo-Yu RY Sheng Chun-Quan CQ Miao Chao-Yu CY
Scientific reports 20150604
Nicotinamide phosphoribosyltransferase (NAMPT) is a promising anticancer target. Using high throughput screening system targeting NAMPT, we obtained a potent NAMPT inhibitor MS0 (China Patent ZL201110447488.9) with excellent in vitro activity (IC50 = 9.87 ± 1.15 nM) and anti-proliferative activity against multiple human cancer cell lines including stem-like cancer cells. Structure-activity relationship studies yielded several highly effective analogues. These inhibitors specifically bound NAMPT, ...[more]