Ontology highlight
ABSTRACT:
SUBMITTER: Yun T
PROVIDER: S-EPMC7309560 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Yun Taikangxiang T Wang Juan J Yang Jun J Huang Wenjing W Lai Luhua L Tan Wenfu W Liu Ying Y
Frontiers in chemistry 20200616
The aberrant activation of hedgehog (Hh) signaling pathway is closely related to human diseases. The upstream protein, N-terminal product of sonic hedgehog (ShhN) is overexpressed in many cancers and considered as a promising antitumor target. Inhibitors that bind to ShhN and break its interaction with the 12-transmembrane glycoprotein patched (Ptch) protein are highly wanted to tune down the abnormal Hh pathway activation. However, research of ShhN inhibitors remains lacking. In this paper, we ...[more]