Ontology highlight
ABSTRACT:
SUBMITTER: Gatto F
PROVIDER: S-EPMC4603759 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Gatto Francesco F Miess Heike H Schulze Almut A Nielsen Jens J
Scientific reports 20150604
Flux balance analysis is the only modelling approach that is capable of producing genome-wide predictions of gene essentiality that may aid to unveil metabolic liabilities in cancer. Nevertheless, a systemic validation of gene essentiality predictions by flux balance analysis is currently missing. Here, we critically evaluated the accuracy of flux balance analysis in two cancer types, clear cell renal cell carcinoma (ccRCC) and prostate adenocarcinoma, by comparison with large-scale experiments ...[more]