Ontology highlight
ABSTRACT:
SUBMITTER: Ribas-Latre A
PROVIDER: S-EPMC4603780 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Ribas-Latre Aleix A Baselga-Escudero Laura L Casanova Ester E Arola-Arnal Anna A Salvadó M-Josepa MJ Bladé Cinta C Arola Lluís L
Scientific reports 20150608
Metabolism follows circadian rhythms, which are driven by peripheral clocks. Clock genes in the liver are entrained by daytime meals and food components. Proanthocyanidins (PAs), the most abundant flavonoids in the human diet, modulate lipid and glucose metabolism. The aim of this study was to determine whether PAs could adjust the clock system in the liver. Male Wistar rats were orally gavaged with 250 mg grape seed proanthocyanidin extract (GSPE)/kg body weight at zeitgeber time (ZT) 0 (light ...[more]