Ontology highlight
ABSTRACT:
SUBMITTER: Lin JB
PROVIDER: S-EPMC5104206 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Lin Jonathan B JB Kubota Shunsuke S Ban Norimitsu N Yoshida Mitsukuni M Santeford Andrea A Sene Abdoulaye A Nakamura Rei R Zapata Nicole N Kubota Miyuki M Tsubota Kazuo K Yoshino Jun J Imai Shin-Ichiro SI Apte Rajendra S RS
Cell reports 20160901 1
Photoreceptor death is the endpoint of many blinding diseases. Identifying unifying pathogenic mechanisms in these diseases may offer global approaches for facilitating photoreceptor survival. We found that rod or cone photoreceptor-specific deletion of nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enzyme in the major NAD(+) biosynthetic pathway beginning with nicotinamide, caused retinal degeneration. In both cases, we could rescue vision with nicotinamide mononucleotide (NM ...[more]