Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia.
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ABSTRACT:
SUBMITTER: Mukai J
PROVIDER: S-EPMC4603834 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia.
Mukai Jun J Tamura Makoto M Fénelon Karine K Rosen Andrew M AM Spellman Timothy J TJ Kang Rujun R MacDermott Amy B AB Karayiorgou Maria M Gordon Joshua A JA Gogos Joseph A JA
Neuron 20150423 3
22q11.2 deletion carriers show specific cognitive deficits, and ∼30% of them develop schizophrenia. One of the disrupted genes is ZDHHC8, which encodes for a palmitoyltransferase. We show that Zdhhc8-deficient mice have reduced palmitoylation of proteins that regulate axonal growth and branching. Analysis of axonal projections of pyramidal neurons from both Zdhhc8-deficient and Df(16)A(+/-) mice, which model the 22q11.2 deletion, revealed deficits in axonal growth and terminal arborization, whic ...[more]
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