Ontology highlight
ABSTRACT:
SUBMITTER: Lorenzo DN
PROVIDER: S-EPMC6681763 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Lorenzo Damaris N DN Badea Alexandra A Zhou Ruobo R Mohler Peter J PJ Zhuang Xiaowei X Bennett Vann V
Proceedings of the National Academy of Sciences of the United States of America 20190617 31
βII-spectrin is the generally expressed member of the β-spectrin family of elongated polypeptides that form micrometer-scale networks associated with plasma membranes. We addressed in vivo functions of βII-spectrin in neurons by knockout of βII-spectrin in mouse neural progenitors. βII-spectrin deficiency caused severe defects in long-range axonal connectivity and axonal degeneration. βII-spectrin-null neurons exhibited reduced axon growth, loss of actin-spectrin-based periodic membrane skeleton ...[more]