Ontology highlight
ABSTRACT:
SUBMITTER: Tookmanian EM
PROVIDER: S-EPMC4603873 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Tookmanian Elise M EM Fenlon Edward E EE Brewer Scott H SH
RSC advances 20141202 2
Two new azidophenylalanine residues (<b>3</b> and <b>4</b>) have been synthesized and, in combination with 4-azido-L-phenylalanine (<b>1</b>) and 4-azidomethyl-L-phenylalanine (<b>2</b>), form a series of unnatural amino acids (UAAs) containing the azide vibrational reporter at varying distances from the aromatic ring of phenylalanine. These UAAs were designed to probe protein hydration with high spatial resolution by utilizing the large extinction coefficient and environmental sensitivity of th ...[more]