Ontology highlight
ABSTRACT:
SUBMITTER: Kohn M
PROVIDER: S-EPMC4604341 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Köhn Marcel M Ihling Christian C Sinz Andrea A Krohn Knut K Hüttelmaier Stefan S
Genes & development 20151001 19
We demonstrate that the Y3/Y3** noncoding RNAs (ncRNAs) bind to the CPSF (cleavage and polyadenylation specificity factor) and that Y3** associates with the 3' untranslated region (UTR) of histone pre-mRNAs. The depletion of Y3** impairs the 3' end processing of histone pre-mRNAs as well as the formation and protein dynamics of histone locus bodies (HLBs), the site of histone mRNA synthesis and processing. HLB morphology is also disturbed by knockdown of the CPSF but not the U7-snRNP components. ...[more]