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Emergence of Raoultella ornithinolytica coproducing IMP-4 and KPC-2 carbapenemases in China.

ABSTRACT: We report here the emergence of seven IMP-4-producing Raoultella ornithinolytica isolates obtained from one patient. All isolates carried the blaIMP-4 carbapenemase gene, five isolates also carried blaSHV-12, four contained blaTEM-1, and one contained blaOXA-1. Notably, the R. ornithinolytica isolate Ro25724 also expressed Klebsiella pneumoniae carbapenemase (KPC)-2. The blaKPC-2 gene was located on a Tn3-Tn4401 integration structure on a plasmid of ?450 kb. This is the first description of the coexistence of blaKPC-2 and blaIMP-4 from the genus Raoultella.

SUBMITTER: Zheng B

PROVIDER: S-EPMC4604418 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Emergence of Raoultella ornithinolytica coproducing IMP-4 and KPC-2 carbapenemases in China.

Zheng Beiwen B Zhang Jing J Ji Jinru J Fang Yunhui Y Shen Ping P Ying Chaoqun C Lv Jifang J Xiao Yonghong Y Li Lanjuan L

Antimicrobial agents and chemotherapy 20150817 11

We report here the emergence of seven IMP-4-producing Raoultella ornithinolytica isolates obtained from one patient. All isolates carried the blaIMP-4 carbapenemase gene, five isolates also carried blaSHV-12, four contained blaTEM-1, and one contained blaOXA-1. Notably, the R. ornithinolytica isolate Ro25724 also expressed Klebsiella pneumoniae carbapenemase (KPC)-2. The blaKPC-2 gene was located on a Tn3-Tn4401 integration structure on a plasmid of ∼450 kb. This is the first description of the ...[more]

PMID: 26282422

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