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Emergence of Colistin Resistance Gene mcr-8 and Its Variant in Raoultella ornithinolytica.


ABSTRACT: Recently, a novel mobile colistin resistance gene, mcr-8, was identified in Klebsiella pneumoniae. Here, we report the identification of mcr-8 and its variant, mcr-8.4, in Raoultella ornithinolytica isolates which also belong to Enterobacteriaceae family. The mcr-8 gene was located on transferrable plasmids with difference sizes. Notably, the transferability of mcr-8-carrying plasmids was enhanced once they entered into Escherichia coli hosts and multiple ?-lactamase genes could co-transfer with mcr-8. These findings expand our knowledge of mcr-8-carrying bacterial species.

SUBMITTER: Wang X 

PROVIDER: S-EPMC6384272 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Emergence of Colistin Resistance Gene <i>mcr-8</i> and Its Variant in <i>Raoultella ornithinolytica</i>.

Wang Xiaoming X   Wang Yao Y   Zhou Ying Y   Wang Zheng Z   Wang Yang Y   Zhang Suxia S   Shen Zhangqi Z  

Frontiers in microbiology 20190215


Recently, a novel mobile colistin resistance gene, <i>mcr-8</i>, was identified in <i>Klebsiella pneumoniae</i>. Here, we report the identification of <i>mcr-8</i> and its variant, <i>mcr-8.4</i>, in <i>Raoultella ornithinolytica</i> isolates which also belong to Enterobacteriaceae family. The <i>mcr-8</i> gene was located on transferrable plasmids with difference sizes. Notably, the transferability of <i>mcr-8</i>-carrying plasmids was enhanced once they entered into <i>Escherichia coli</i> hos  ...[more]

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