Emergence of Colistin Resistance Gene mcr-8 and Its Variant in Raoultella ornithinolytica.
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ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC6384272 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Emergence of Colistin Resistance Gene <i>mcr-8</i> and Its Variant in <i>Raoultella ornithinolytica</i>.
Wang Xiaoming X Wang Yao Y Zhou Ying Y Wang Zheng Z Wang Yang Y Zhang Suxia S Shen Zhangqi Z
Frontiers in microbiology 20190215
Recently, a novel mobile colistin resistance gene, <i>mcr-8</i>, was identified in <i>Klebsiella pneumoniae</i>. Here, we report the identification of <i>mcr-8</i> and its variant, <i>mcr-8.4</i>, in <i>Raoultella ornithinolytica</i> isolates which also belong to Enterobacteriaceae family. The <i>mcr-8</i> gene was located on transferrable plasmids with difference sizes. Notably, the transferability of <i>mcr-8</i>-carrying plasmids was enhanced once they entered into <i>Escherichia coli</i> hos ...[more]
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