Ontology highlight
ABSTRACT:
SUBMITTER: Bizarro J
PROVIDER: S-EPMC4605303 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Bizarro Jonathan J Dodré Maxime M Huttin Alexandra A Charpentier Bruno B Schlotter Florence F Branlant Christiane C Verheggen Céline C Massenet Séverine S Bertrand Edouard E
Nucleic acids research 20150814 18
The Sm proteins are loaded on snRNAs by the SMN complex, but how snRNP-specific proteins are assembled remains poorly characterized. U4 snRNP and box C/D snoRNPs have structural similarities. They both contain the 15.5K and proteins with NOP domains (PRP31 for U4, NOP56/58 for snoRNPs). Biogenesis of box C/D snoRNPs involves NUFIP and the HSP90/R2TP chaperone system and here, we explore the function of this machinery in U4 RNP assembly. We show that yeast Prp31 interacts with several components ...[more]