Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC5769618 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Li Yuanyuan Y Zhao Lu L Yuan Shiaulou S Zhang Jiefang J Sun Zhaoxia Z
Development (Cambridge, England) 20171107 24
Pontin (Ruvbl1) and Reptin (Ruvbl2) are closely related AAA ATPases. They are components of the Ruvbl1-Ruvbl2-Tah1-Pih1 (R2TP) complexes that function as co-chaperones for the assembly of multiple macromolecular protein complexes. Here, we show that Pontin is essential for cilia motility in both zebrafish and mouse and that Pontin and Reptin function cooperatively in this process. Zebrafish <i>pontin</i> mutants display phenotypes tightly associated with cilia defects, and cilia motility is lost ...[more]