Ontology highlight
ABSTRACT:
SUBMITTER: Tosoni E
PROVIDER: S-EPMC4605322 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Tosoni Elena E Frasson Ilaria I Scalabrin Matteo M Perrone Rosalba R Butovskaya Elena E Nadai Matteo M Palù Giorgio G Fabris Dan D Richter Sara N SN
Nucleic acids research 20150909 18
Folding of the LTR promoter into dynamic G-quadruplex conformations has been shown to suppress its transcriptional activity in HIV-1. Here we sought to identify the proteins that control the folding of this region of proviral genome by inducing/stabilizing G-quadruplex structures. The implementation of electrophorethic mobility shift assay and pull-down experiments coupled with mass spectrometric analysis revealed that the cellular protein nucleolin is able to specifically recognize G-quadruplex ...[more]