Ontology highlight
ABSTRACT:
SUBMITTER: Yuan L
PROVIDER: S-EPMC3648798 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Yuan Libo L Tian Tian T Chen Yuqi Y Yan Shengyong S Xing Xiwen X Zhang Zhengan Z Zhai Qianqian Q Xu Liang L Wang Shaoru S Weng Xiaocheng X Yuan Bifeng B Feng Yuqi Y Zhou Xiang X
Scientific reports 20130101
Existence of G-quadruplex DNA in vivo always attract widespread interest in the field of biology and biological chemistry. We reported our findings for the existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy. Probes for selective G-quadruplex cross-linking was designed and synthesized that show high selectivity for G-quadruplex cross-linking. Further biological studies demonstrated its good inhibition activity against murine m ...[more]