Ontology highlight
ABSTRACT:
SUBMITTER: Tsunematsu Y
PROVIDER: S-EPMC4605568 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Tsunematsu Yuta Y Fukutomi Manami M Saruwatari Takayoshi T Noguchi Hiroshi H Hotta Kinya K Tang Yi Y Watanabe Kenji K
Angewandte Chemie (International ed. in English) 20140618 32
Pseurotins comprise a family of structurally related Aspergillal natural products having interesting bioactivity. However, little is known about the biosynthetic steps involved in the formation of their complex chemical features. Systematic deletion of the pseurotin biosynthetic genes in A. fumigatus and in vivo and in vitro characterization of the tailoring enzymes to determine the biosynthetic intermediates, and the gene products responsible for the formation of each intermediate, are describe ...[more]