Ontology highlight
ABSTRACT:
SUBMITTER: Salom D
PROVIDER: S-EPMC4605854 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Salom David D Padayatti Pius S PS Palczewski Krzysztof K
Methods in cell biology 20130101
Oligomerization is one of several mechanisms that can regulate the activity of G protein-coupled receptors (GPCRs), but little is known about the structure of GPCR oligomers. Crystallography and NMR are the only methods able to reveal the details of receptor-receptor interactions at an atomic level, and several GPCR homodimers already have been described from crystal structures. Two clusters of symmetric interfaces have been identified from these structures that concur with biochemical data, one ...[more]