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Structural Studies of G Protein-Coupled Receptors.

ABSTRACT: G protein-coupled receptors (GPCRs) constitute the largest and the most physiologically important membrane protein family that recognizes a variety of environmental stimuli, and are drug targets in the treatment of numerous diseases. Recent progress on GPCR structural studies shed light on molecular mechanisms of GPCR ligand recognition, activation and allosteric modulation, as well as structural basis of GPCR dimerization. In this review, we will discuss the structural features of GPCRs and structural insights of different aspects of GPCR biological functions.

SUBMITTER: Zhang D

PROVIDER: S-EPMC4625064 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Structural Studies of G Protein-Coupled Receptors.

Zhang Dandan D Zhao Qiang Q Wu Beili B

Molecules and cells 20151015 10

G protein-coupled receptors (GPCRs) constitute the largest and the most physiologically important membrane protein family that recognizes a variety of environmental stimuli, and are drug targets in the treatment of numerous diseases. Recent progress on GPCR structural studies shed light on molecular mechanisms of GPCR ligand recognition, activation and allosteric modulation, as well as structural basis of GPCR dimerization. In this review, we will discuss the structural features of GPCRs and str ...[more]

PMID: 26467290

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