Ontology highlight
ABSTRACT:
SUBMITTER: Anusha S
PROVIDER: S-EPMC4607480 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Anusha Sebastian S Cp Baburajeev B Mohan Chakrabhavi Dhananjaya CD Mathai Jessin J Rangappa Shobith S Mohan Surender S Chandra Paricharak Shardul S Mervin Lewis L Fuchs Julian E JE M Mahedra M Bender Andreas A Basappa Rangappa Kanchugarakoppal S KS
PloS one 20151015 10
In this work, we describe the 'green' synthesis of novel 6-(adamantan-1-yl)-2-substituted-imidazo[2,1-b][1,3,4]thiadiazoles (AITs) by ring formation reactions using 1-(adamantan-1-yl)-2-bromoethanone and 5-alkyl/aryl-2-amino1,3,4-thiadiazoles on a nano material base in ionic liquid media. Given the established activity of imidazothiadiazoles against M. tuberculosis, we next examined the anti-TB activity of AITs against the H37Rv strain using Alamar blue assay. Among the tested compounds 6-(adama ...[more]