Ontology highlight
ABSTRACT:
SUBMITTER: Alcantara Llaguno SR
PROVIDER: S-EPMC4607935 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Alcantara Llaguno Sheila R SR Wang Zilai Z Sun Daochun D Chen Jian J Xu Jing J Kim Euiseok E Hatanpaa Kimmo J KJ Raisanen Jack M JM Burns Dennis K DK Johnson Jane E JE Parada Luis F LF
Cancer cell 20151001 4
A central question in glioblastoma multiforme (GBM) research is the identity of the tumor-initiating cell, and its contribution to the malignant phenotype and genomic state. We examine the potential of adult lineage-restricted progenitors to induce fully penetrant GBM using CNS progenitor-specific inducible Cre mice to mutate Nf1, Trp53, and Pten. We identify two phenotypically and molecularly distinct GBM subtypes governed by identical driver mutations. We demonstrate that the two subtypes aris ...[more]