Ontology highlight
ABSTRACT:
SUBMITTER: Rinkevich Y
PROVIDER: S-EPMC3812235 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Rinkevich Yuval Y Lindau Paul P Ueno Hiroo H Longaker Michael T MT Weissman Irving L IL
Nature 20110824 7361
The regrowth of amputated limbs and the distal tips of digits represent models of tissue regeneration in amphibians, fish and mice. For decades it had been assumed that limb regeneration derived from the blastema, an undifferentiated pluripotent cell population thought to be derived from mature cells via dedifferentiation. Here we show that a wide range of tissue stem/progenitor cells contribute towards the restoration of the mouse distal digit. Genetic fate mapping and clonal analysis of indivi ...[more]