Ontology highlight
ABSTRACT:
SUBMITTER: Gisslinger H
PROVIDER: S-EPMC4608390 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Gisslinger Heinz H Zagrijtschuk Oleh O Buxhofer-Ausch Veronika V Thaler Josef J Schloegl Ernst E Gastl Guenther A GA Wolf Dominik D Kralovics Robert R Gisslinger Bettina B Strecker Karin K Egle Alexander A Melchardt Thomas T Burgstaller Sonja S Willenbacher Ella E Schalling Martin M Them Nicole C NC Kadlecova Pavla P Klade Christoph C Greil Richard R
Blood 20150810 15
In this prospective, open-label, multicenter phase 1/2 dose escalation study, we used a next-generation, mono-pegylated interferon (IFN) α-2b isoform, ropeginterferon alfa-2b. The unique feature of ropeginterferon alfa-2b is a longer elimination half-life, which allows administration every 2 weeks. We present data from 51 polycythemia vera patients. The main goal was to define the maximum tolerated dose and to assess safety and efficacy. A dose range of 50 to 540 µg was tested without the appear ...[more]