Ontology highlight
ABSTRACT:
SUBMITTER: Verger E
PROVIDER: S-EPMC6172224 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Verger Emmanuelle E Soret-Dulphy Juliette J Maslah Nabih N Roy Lydia L Rey Jerome J Ghrieb Zineb Z Kralovics Robert R Gisslinger Heinz H Grohmann-Izay Barbara B Klade Christoph C Chomienne Christine C Giraudier Stéphane S Cassinat Bruno B Kiladjian Jean-Jacques JJ
Blood cancer journal 20181004 10
Polycythemia vera is characterized by the acquisition of the JAK2V617F mutation. Recommended treatments include hydroxyurea and interferon-alpha. Several groups have reported a reduction in the JAK2 mutant allele burden in interferon-treated patients, but significance of this observation is questioned. We characterized the activity of ropeginterferon alpha-2b, a novel form of interferon-alpha recently shown to be safe and efficacious in polycythemia vera. Ropeginterferon was able to inhibit the ...[more]