Ontology highlight
ABSTRACT:
SUBMITTER: Huentelman MJ
PROVIDER: S-EPMC4608790 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Huentelman Matthew J MJ Muppana Leela L Corneveaux Jason J JJ Dinu Valentin V Pruzin Jeremy J JJ Reiman Rebecca R Borish Cassie N CN De Both Matt M Ahmed Amber A Todorov Alexandre A Cloninger C Robert CR Zhang Rui R Ma Jie J Gallitano Amelia L AL
PloS one 20151016 10
We have previously hypothesized a biological pathway of activity-dependent synaptic plasticity proteins that addresses the dual genetic and environmental contributions to schizophrenia. Accordingly, variations in the immediate early gene EGR3, and its target ARC, should influence schizophrenia susceptibility. We used a pooled Next-Generation Sequencing approach to identify variants across these genes in U.S. populations of European (EU) and African (AA) descent. Three EGR3 and one ARC SNP were s ...[more]