Ontology highlight
ABSTRACT:
SUBMITTER: Rajapakse CS
PROVIDER: S-EPMC4608832 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Rajapakse Chandima S K CS Lisai Maryna M Deregnaucourt Christiane C Sinou Véronique V Latour Christine C Roy Dipankar D Schrével Joseph J Sánchez-Delgado Roberto A RA
PloS one 20151016 10
The efficacy of chloroquine, once the drug of choice in the fight against Plasmodium falciparum, is now severely limited due to widespread resistance. Amodiaquine is one of the most potent antimalarial 4-aminoquinolines known and remains effective against chloroquine-resistant parasites, but toxicity issues linked to a quinone-imine metabolite limit its clinical use. In search of new compounds able to retain the antimalarial activity of amodiaquine while circumventing quinone-imine metabolite to ...[more]