Dataset Information

Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation.

ABSTRACT: Group 3 ILCs (ILC3s) are innate sources of IL-22 and IL-17 and include lymphoid tissue-inducer (LTi)-like and NKp46(+) subsets. Both depend on ROR?t and aryl hydrocarbon receptor, but NKp46(+)ILC3s also require Notch and T-bet for their development and are transcriptionally distinct. The extent to which these subsets have unique functions, especially in the context of T cell- and B cell-sufficient mice, remains largely unclear. To investigate the specific function of NKp46(+)ILC3s among other ILC3 subsets and T cells, we generated mice selectively lacking NKp46(+)ILC3s or all ILC3s and crossed them to T cell-deficient mice, thus maintaining B cells in all mice. In mice lacking T cells, NKp46(+)ILC3s were sufficient to promote inflammatory monocyte accumulation in the anti-CD40 innate colitis model through marked production of GM-CSF. In T cell-competent mice, lack of NKp46(+)ILCs had no impact on control of intestinal C. rodentium infection, whereas lack of all ILC3s partially impaired bacterial control. Thus, NKp46(+)ILC3s have a unique capacity to promote inflammation through GM-CSF-induced accumulation of inflammatory monocytes, but are superseded by LTi-like ILC3s and T cells in controlling intestinal bacterial infection.

SUBMITTER: Song C

PROVIDER: S-EPMC4612098 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation.

Song Christina C Lee Jacob S JS Gilfillan Susan S Robinette Michelle L ML Newberry Rodney D RD Stappenbeck Thaddeus S TS Mack Matthias M Cella Marina M Colonna Marco M

The Journal of experimental medicine 20151012 11

Group 3 ILCs (ILC3s) are innate sources of IL-22 and IL-17 and include lymphoid tissue-inducer (LTi)-like and NKp46(+) subsets. Both depend on RORγt and aryl hydrocarbon receptor, but NKp46(+)ILC3s also require Notch and T-bet for their development and are transcriptionally distinct. The extent to which these subsets have unique functions, especially in the context of T cell- and B cell-sufficient mice, remains largely unclear. To investigate the specific function of NKp46(+)ILC3s among other IL ...[more]

PMID: 26458769

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Dataset Information

Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation.

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Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation.

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