Cooperative interplay of let-7 mimic and HuR with MYC RNA.
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ABSTRACT:
SUBMITTER: Gunzburg MJ
PROVIDER: S-EPMC4612438 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Cooperative interplay of let-7 mimic and HuR with MYC RNA.
Gunzburg Menachem J MJ Sivakumaran Andrew A Pendini Nicole R NR Yoon Je-Hyun JH Gorospe Myriam M Wilce Matthew C J MC Wilce Jacqueline A JA
Cell cycle (Georgetown, Tex.) 20150715 17
Both RNA-binding proteins (RBP) and miRNA play important roles in the regulation of mRNA expression, often acting together to regulate a target mRNA. In some cases the RBP and miRNA have been reported to act competitively, but in other instances they function cooperatively. Here, we investigated HuR function as an enhancer of let-7-mediated translational repression of c-Myc despite the separation of their binding sites. Using an in vitro system, we determined that a let-7 mimic, consisting of si ...[more]
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