Ontology highlight
ABSTRACT:
SUBMITTER: Bateman NW
PROVIDER: S-EPMC4612617 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Bateman Nicholas W NW Jaworski Elizabeth E Ao Wei W Wang Guisong G Litzi Tracy T Dubil Elizabeth E Marcus Charlotte C Conrads Kelly A KA Teng Pang-ning PN Hood Brian L BL Phippen Neil T NT Vasicek Lisa A LA McGuire William P WP Paz Keren K Sidransky David D Hamilton Chad A CA Maxwell G Larry GL Darcy Kathleen M KM Conrads Thomas P TP
Journal of proteome research 20150319 4
A majority of high-grade (HG) serous ovarian cancer (SOC) patients develop resistant disease despite high initial response rates to platinum/paclitaxel-based chemotherapy. We identified shed/secreted proteins in preclinical models of paclitaxel-resistant human HGSOC models and correlated these candidate proteins with patient outcomes using public data from HGSOC patients. Proteomic analyses of a HGSOC cell line secretome was compared to those from a syngeneic paclitaxel-resistant variant and fro ...[more]