Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Alvaro M
PROVIDER: S-EPMC4613212 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
García-Álvaro María M Addante Annalisa A Roncero Cesáreo C Fernández Margarita M Fabregat Isabel I Sánchez Aránzazu A Herrera Blanca B
International journal of molecular sciences 20150828 9
The study of bone morphogenetic proteins (BMPs) role in tumorigenic processes, and specifically in the liver, has gathered importance in the last few years. Previous studies have shown that BMP9 is overexpressed in about 40% of hepatocellular carcinoma (HCC) patients. In vitro data have also shown evidence that BMP9 has a pro-tumorigenic action, not only by inducing epithelial to mesenchymal transition (EMT) and migration, but also by promoting proliferation and survival in liver cancer cells. H ...[more]