Transcriptional regulation of FOXP3 requires integrated activation of both promoter and CNS regions in tumor-induced CD8⁺ Treg cells.

ABSTRACT: T-regulatory cells are an upsurge in the tumor microenvironment and induce immune-evasion. CD4⁺ Treg cells are well characterized whereas the role of CD8⁺ Tregs in cancer has recently started to crease attention. Here, we report an augmentation CD8⁺FOXP3⁺ Tregs in breast tumor microenvironment. FOXP3, the lineage-specific transcription factor, is a dominant regulator of Treg cell development and function. FOXP3 is induced preferentially by divergent signaling in CD4⁺ Treg cells. But how FOXP3 is induced and maintained in tumor-CD8⁺ Tregs is the Cinderella of the investigation. We observed that RUNX3, a CD8⁺ lineage-specific transcription factor, binds at the FOXP3-promoter to induce its transcription. In addition

SUBMITTER: Chakraborty S 

PROVIDER: S-EPMC5431671 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature