Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Blanco A
PROVIDER: S-EPMC4614342 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Sánchez-Blanco Adolfo A Rodríguez-Matellán Alberto G AG Reis-Sobreiro Mariana M Sáenz-Narciso Beatriz B Cabello Juan J Mohler William A WA Mollinedo Faustino F
Cell cycle (Georgetown, Tex.) 20140101 21
Drugs capable of specifically recognizing and killing cancer cells while sparing healthy cells are of great interest in anti-cancer therapy. An example of such a drug is edelfosine, the prototype molecule of a family of synthetic lipids collectively known as antitumor lipids (ATLs). A better understanding of the selectivity and the mechanism of action of these compounds would lead to better anticancer treatments. Using Caenorhabditis elegans, we modeled key features of the ATL selectivity agains ...[more]