Ontology highlight
ABSTRACT:
SUBMITTER: Ling H
PROVIDER: S-EPMC4614521 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Ling Hongbo H Hanashiro Kazuhiko K Luong Tran H TH Benavides Luis L Fukasawa Kenji K
Cell cycle (Georgetown, Tex.) 20150101 4
The presence of more than 2 centrosomes (centrosome amplification) leads to defective mitosis and chromosome segregation errors, is frequently found in a variety of cancer types, and believed to be the major cause of chromosome instability. One mechanism for generation of amplified centrosomes is over-duplication of centrosomes in a single cell cycle, which is expected to occur when cells are temporarily arrested. There are a growing number of kinases that are critical for induction and promotio ...[more]