Ontology highlight
ABSTRACT:
SUBMITTER: Kim DH
PROVIDER: S-EPMC6662699 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Kim Dong Hyun DH Ahn Jong Seog JS Han Ho Jin HJ Kim Hye-Min HM Hwang Joonsung J Lee Kyung Ho KH Cha-Molstad Hyunjoo H Ryoo In-Ja IJ Jang Jae-Hyuk JH Ko Sung-Kyun SK Yang Jin Ok JO Lee Hee Gu HG Lee Sangku S Song Eun Joo EJ Kim Jin Young JY Huh Yang Hoon YH Kwon Yong Tae YT Soung Nak-Kyun NK Kim Bo Yeon BY
Cell death & disease 20190729 8
The initiation of centrosome duplication is regulated by the Plk4/STIL/hsSAS-6 axis; however, the involvement of other centrosomal proteins in this process remains unclear. In this study, we demonstrate that Cep131 physically interacts with Plk4 following phosphorylation of residues S21 and T205. Localizing at the centriole, phosphorylated Cep131 has an increased capability to interact with STIL, leading to further activation and stabilization of Plk4 for initiating centrosome duplication. Moreo ...[more]