Ontology highlight
ABSTRACT:
SUBMITTER: Cefalu S
PROVIDER: S-EPMC4615066 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Cefalù S S Lena A M AM Vojtesek B B Musarò A A Rossi A A Melino G G Candi E E
Cell cycle (Georgetown, Tex.) 20150101 6
p53 family members, p63 and p73, play a role in controlling early stage of myogenic differentiation. We demonstrated that TAp63gamma, unlike the other p53 family members, is markedly up-regulated during myogenic differentiation in murine C2C7 cell line. We also found that myotubes formation was inhibited upon TAp63gamma knock-down, as also indicated by atrophyic myotubes and reduction of myoblasts fusion index. Analysis of TAp63gamma-dependend transcripts identified several target genes involved ...[more]