Ontology highlight
ABSTRACT:
SUBMITTER: Chua CY
PROVIDER: S-EPMC4615268 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Chua C Y CY Liu Y Y Granberg K J KJ Hu L L Haapasalo H H Annala M J MJ Cogdell D E DE Verploegen M M Moore L M LM Fuller G N GN Nykter M M Cavenee W K WK Zhang W W
Oncogene 20150420 6
Insulin-like growth factor binding protein 2 (IGFBP2) is a pleiotropic oncogenic protein that has both extracellular and intracellular functions. Despite a clear causal role in cancer development, the tumor-promoting mechanisms of IGFBP2 are poorly understood. The contributions of intracellular IGFBP2 to tumor development and progression are also unclear. Here we present evidence that both exogenous IGFBP2 treatment and cellular IGFBP2 overexpression lead to aberrant activation of epidermal grow ...[more]