Ontology highlight
ABSTRACT:
SUBMITTER: Li T
PROVIDER: S-EPMC7816098 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Li Ting T Zhang Chao C Zhao Gang G Zhang Xinwei X Hao Mengze M Hassan Shafat S Zhang Min M Zheng Hong H Yang Da D Liu Liang L Mehraein-Ghomi Farideh F Bai Xu X Chen Kexin K Zhang Wei W Yang Jilong J
Cancer letters 20200229
Immunotherapy targeting the PD-1/PD-L1 receptor has achieved great success in melanoma patients. Although many studies have addressed the underlying mechanisms involved in the blockade of PD-1/PD-L1 and the consequent modulation of the immune system, the mechanisms of PD-L1 upregulation and reliable biomarkers to predict the efficacy of anti-PD-1/PD-L1 therapy remain unknown. The present study demonstrates the correlation between IGFBP2 and PD-L1, revealing a novel immune-associated tumor functi ...[more]