Requirement for CRIF1 in RNA interference and Dicer-2 stability.
Ontology highlight
ABSTRACT:
SUBMITTER: Lim SJ
PROVIDER: S-EPMC4615304 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Requirement for CRIF1 in RNA interference and Dicer-2 stability.
Lim Su Jun SJ Scott Anthony A Xiong Xiao-Peng XP Vahidpour Shabnam S Karijolich John J Guo Dongdong D Pei Shanshan S Yu Yi-Tao YT Zhou Rui R Li Willis X WX
RNA biology 20140101 9
RNA interference (RNAi) is a eukaryotic gene-silencing system. Although the biochemistry of RNAi is relatively well defined, how this pathway is regulated remains incompletely understood. To identify genes involved in regulating the RNAi pathway, we screened for genetic mutations in Drosophila that alter the efficiency of RNAi. We identified the Drosophila homolog of the mammalian CR6-interacting factor 1 (CRIF1), also known as growth arrest and DNA-damage-inducible 45-gamma interacting protein ...[more]
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