Ontology highlight
ABSTRACT:
SUBMITTER: El Ouaamari A
PROVIDER: S-EPMC4615688 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
El Ouaamari Abdelfattah A Zhou Jian-Ying JY Liew Chong Wee CW Shirakawa Jun J Dirice Ercument E Gedeon Nicholas N Kahraman Sevim S De Jesus Dario F DF Bhatt Shweta S Kim Jong-Seo JS Clauss Therese Rw TR Camp David G DG Smith Richard D RD Qian Wei-Jun WJ Kulkarni Rohit N RN
Journal of proteome research 20150730 8
Compensatory islet response is a distinct feature of the prediabetic insulin-resistant state in humans and rodents. To identify alterations in the islet proteome that characterize the adaptive response, we analyzed islets from 5 month old male control, high-fat diet fed (HFD), or obese ob/ob mice by LC-MS/MS and quantified ~1100 islet proteins (at least two peptides) with a false discovery rate < 1%. Significant alterations in abundance were observed for ~350 proteins among groups. The majority ...[more]