Ontology highlight
ABSTRACT:
SUBMITTER: Okada T
PROVIDER: S-EPMC1885613 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Okada Terumasa T Liew Chong Wee CW Hu Jiang J Hinault Charlotte C Michael M Dodson MD Krtzfeldt Jan J Yin Catherine C Holzenberger Martin M Stoffel Markus M Kulkarni Rohit N RN
Proceedings of the National Academy of Sciences of the United States of America 20070406 21
Insulin and insulin-like growth factor 1 (IGF1) are ubiquitous growth factors that regulate proliferation in most mammalian tissues including pancreatic islets. To explore the specificity of insulin receptors in compensatory beta-cell growth, we examined two models of insulin resistance. In the first model, we used liver-specific insulin receptor knockout (LIRKO) mice, which exhibit hyperinsulinemia without developing diabetes due to a compensatory increase in beta-cell mass. LIRKO mice, also la ...[more]