Ontology highlight
ABSTRACT:
SUBMITTER: Sellerio AL
PROVIDER: S-EPMC4616026 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Sellerio Alessandro L AL Ciusani Emilio E Ben-Moshe Noa Bossel NB Coco Stefania S Piccinini Andrea A Myers Christopher R CR Sethna James P JP Giampietro Costanza C Zapperi Stefano S La Porta Caterina A M CAM
Scientific reports 20151023
The dynamics of tumor cell populations is hotly debated: do populations derive hierarchically from a subpopulation of cancer stem cells (CSCs), or are stochastic transitions that mutate differentiated cancer cells to CSCs important? Here we argue that regulation must also be important. We sort human melanoma cells using three distinct cancer stem cell (CSC) markers - CXCR6, CD271 and ABCG2 - and observe that the fraction of non-CSC-marked cells first overshoots to a higher level and then returns ...[more]